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Whole genome bisufite sequencing of smoking and non-smoking mother-child pairsBisufite sequencing, RNA-seq and ChIP-Seq data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.

Whole-blood samples of 16 mother-child pairs with differing maternal smoking behaviour were bisulfite treated and sequenced with deep coverage to identify smoking-associated differentially methylated regions.RNA-sequencing and ChIP-sequencing of 4 chromatin marks complete the data set and allow for integrative analyses, functional region annotation and to study the impact of epigenetic changes on gene expression.Longitudinal data spanning several years provides the means to investigate the stability of observed differences of all data types.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000366 Illumina HiSeq 2000 52
EGAD00001002011 64
EGAD00001002012 16
Publications Citations
Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.
Mol Syst Biol 12: 2016 861
Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation.
Sci Rep 6: 2016 28616
Epigenetic biomarkers and preterm birth.
Environ Epigenet 6: 2020 dvaa005