Study
Identification of point mutations, expression perturbations, and gene fusions in T-cell acute lymphoblastic leukemia by RNA-seq
Study ID | Alternative Stable ID | Type |
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EGAS00001000536 | Other |
Study Description
RNA-seq is a promising technology to re-sequence protein-coding genes for the identification of single nucleotide variants, while simultaneously obtaining information on structural variations and gene expression perturbations. T-cell acute lymphoblastic leukemia (T-ALL) is caused by a combination of gene fusions leading to the over-expression of transcription factors reinforced by point mutations in oncogenes and tumor suppressor genes. We asked whether RNA-seq is suitable for the detection of driver mutations in these leukemias. We analyzed 31 T-ALL patient samples and 18 T-ALL cell lines by high-coverage paired-end RNA-seq.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00001000849 |
NA
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Illumina HiSeq 2000 | 50 |
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