Need Help?

Illumina ExomeChip genotyping data from the Cretan Greek isolate collection HELIC MANOLIS

Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies. Here we have genotyped individuals from a Greek population isolate on the Illumina HumanExome Beadchip. The HELIC (Hellenic Isolated Cohorts) MANOLIS (Minoan Isolates) collection focuses on Anogia and surrounding Mylopotamos villages. Recruitment of this population-based sample was primarily carried out at the village medical centres. All individuals were older than 17 years and had to have at least one parent from the Mylopotamos area. **The data may not be used for population genetics analyses.**

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000518 HumanExome_12v1.1_A -GenCall, zCall 1280
Publications Citations
A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates.
Nat Commun 4: 2013 2872
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.
Nat Commun 8: 2017 15606
Very low-depth whole-genome sequencing in complex trait association studies.
Bioinformatics 35: 2019 2555-2561
The transferability of lipid loci across African, Asian and European cohorts.
Nat Commun 10: 2019 4330
Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations.
Sci Rep 12: 2022 1131