Study

PCGP Ph-like ALL

Study ID Alternative Stable ID Type
EGAS00001000654 Other

Study Description

Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alterations activating kinase signaling suggesting Ph-like ALL may be amenable to treatment with tyrosine kinase inhibitors. However, the spectrum of genetic alterations in childhood and adult Ph-like ALL is incompletely understood. Methods: We performed genomic profiling of 1736 B-ALL cases and next-generation sequencing for 160 Ph-like cases. We examined the functional effects of chimeric fusion proteins in mouse cell lines. Results: The frequency of Ph-like ALL rose from 11% in children to 26% in young adults, and was associated with very poor outcome. Kinase-activating alterations were identified in 90% of Ph-like cases, most commonly fusions involving 10 kinase or cytokine receptor genes (ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B and TYK2), and mutations involving ... (Show More)

Study Datasets 6 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000976
WGS DATA FILES FOR SJPhLike
Illumina HiSeq 2000 80
EGAD00001001016
DATA FILES FOR SJPhLike-RNASeq
Illumina HiSeq 2000 125
EGAD00001001054
DATA FILES FOR Ph-likeALL WES
Illumina HiSeq 2000 23
EGAD00001001432
PCGP Germline Study Whole Genome Sequencing
Illumina HiSeq 2000 1337
EGAD00010000596
PCGP Ph-likeALL GEA
837
EGAD00010000598
PCGP Ph-likeALL SNP6
1724

Who archives the data?

Publications

Citations

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