Study
PCGP Ph-like ALL
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001000654 | Other |
Study Description
Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alterations activating kinase signaling suggesting Ph-like ALL may be amenable to treatment with tyrosine kinase inhibitors. However, the spectrum of genetic alterations in childhood and adult Ph-like ALL is incompletely understood. Methods: We performed genomic profiling of 1736 B-ALL cases and next-generation sequencing for 160 Ph-like cases. We examined the functional effects of chimeric fusion proteins in mouse cell lines. Results: The frequency of Ph-like ALL rose from 11% in children to 26% in young adults, and was associated with very poor outcome. Kinase-activating alterations were identified in 90% of Ph-like cases, most commonly fusions involving 10 kinase or cytokine receptor genes (ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B and TYK2), and mutations involving ... (Show More)
Study Datasets 6 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001000976 |
WGS DATA FILES FOR SJPhLike
|
Illumina HiSeq 2000 | 80 |
EGAD00001001016 |
DATA FILES FOR SJPhLike-RNASeq
|
Illumina HiSeq 2000 | 125 |
EGAD00001001054 |
DATA FILES FOR Ph-likeALL WES
|
Illumina HiSeq 2000 | 23 |
EGAD00001001432 |
PCGP Germline Study Whole Genome Sequencing
|
Illumina HiSeq 2000 | 1337 |
EGAD00010000596 |
PCGP Ph-likeALL GEA
|
837 | |
EGAD00010000598 |
PCGP Ph-likeALL SNP6
|
1724 |
Who archives the data?

Publications
Citations
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