Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

We applied multi-region exome sequencing to 10 clear cell renal carcinomas to resolve the genetic architecture, intra tumour heterogeneity and evolutionary histories of these tumours.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001000734	Paired end Illumina sequencing of whole exomes of multiple tumour regions.	Illumina Genome Analyzer IIx Illumina HiSeq 2000 Illumina HiSeq 2500	88

Publications	Citations
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, Varela I, Fisher R, McGranahan N, Matthews N, Santos CR, Martinez P, Phillimore B, Begum S, Rabinowitz A, Spencer-Dene B, Gulati S, Bates PA, Stamp G, Pickering L, Gore M, Nicol DL, Hazell S, Futreal PA, Stewart A, Swanton C. Nat Genet 46: 2014 225-233	786
BAMSE: Bayesian model selection for tumor phylogeny inference among multiple samples. Toosi H, Moeini A, Hajirasouliha I. BMC Bioinformatics 20: 2019 282	6
Phylogenetic Tree Inference: A Top-Down Approach to Track Tumor Evolution. Wu P, Hou L, Zhang Y, Zhang L. Front Genet 10: 2019 1371	3