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UK10K COHORT IMPUTATION

Imputation panel created from UK10K_COHORT_ALSPAC (EGAD00001000740) and UK10K_COHORT_TWINSUK (EGAD00001000741) datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000776 Illumina Genome Analyzer II Illumina HiSeq 2000 3781
Publications Citations
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.
Nat Commun 6: 2015 8111
190
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
Am J Hum Genet 100: 2017 865-884
89
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Nat Commun 9: 2018 321
58
ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.
PLoS Genet 14: 2018 e1007591
21
The impact of non-additive genetic associations on age-related complex diseases.
Nat Commun 12: 2021 2436
38
Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes.
Diabetes 71: 2022 554-565
8
GCAT|Panel, a comprehensive structural variant haplotype map of the Iberian population from high-coverage whole-genome sequencing.
Nucleic Acids Res 50: 2022 2464-2479
4
Whole-genome risk prediction of common diseases in human preimplantation embryos.
Nat Med 28: 2022 513-516
18
Integration of a Cross-Ancestry Polygenic Model With Clinical Risk Factors Improves Breast Cancer Risk Stratification.
JCO Precis Oncol 7: 2023 e2200447
2
Genetic determinants of IgG antibody response to COVID-19 vaccination.
Am J Hum Genet 111: 2024 181-199
0