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Unraveling metastatic progression of breast cancer

To reconstruct the trajectories of BC progression, we performed exome sequencing (Illumina HiSeq2000, Truseq DNA sample preparation kit v2 and Exome Enrichment Kit v2; alignement done with BWA, substitutions and indels called with GATK and DINDEL respectively) coupled to validation by Sequenom and deep re-sequencing (ongoing), as well as copy number (CN) analyses (Oncoscan, Affymetrix) on DNA from matched primary (n=1-6/pt), axillary lymph node (ALN, n=1-6 for 4 pts), local recurrence (for 1 pt) and distant metastatic (n=1-5/pt) FFPE samples obtained from an autopsy series of 10 BC pts.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000836 Illumina HiSeq 2000 49
Publications Citations
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.
Nat Commun 8: 2017 14944
Minimal functional driver gene heterogeneity among untreated metastases.
Science 361: 2018 1033-1037
Phylogenetic Tree Inference: A Top-Down Approach to Track Tumor Evolution.
Front Genet 10: 2019 1371