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Exploration_of__mutational_processes_in_human_cancer_cell_lines__Exome

Approximately 25 cell lines representative of 11 mutation signatures have been selected and will be grown from a single cell, referred to as parental clone, for a period of 3 months to allow accumulation of mutations. Following that period, we will obtain 2 subclones from each of the parental clone for sequencing analysis. In total we will be sequencing 2 parental clones and 4 subclones per cell line for approximately 25 cell lines.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004201 Illumina HiSeq 2000 Illumina HiSeq 2500 75
EGAD00001004203 HiSeq X Ten 192
Publications Citations
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.
Cell 176: 2019 1282-1294.e20
210
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Nature 602: 2022 510-517
46