RNA-seq data from the EUROBATS Project in four tissues: Fat, LCL, Skin and whole Blood.

EUROBATS consists of RNA-seq data for female twins in lisphoblastoide cell lines (LCL), abdominal adipose tissue (Fat), abdominal skin tissue (Skin) and whole blood (Blood). The samples are a combination of MZ twins, DZ twins and singletons. The goal of the project is to find biomarkers related with the ageing process and cellular senescence.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

4 Datasets 26 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Samples
EGAD00001001086	These analysis are the BAM files for the LCLs samples of the EUROBATS samples.	765
EGAD00001001087	RNAseq BAM files for the Skin samples of the EUROBATS project.	672
EGAD00001001088	RNAseq BAM files for the blood samples of the EUROBATS project	391
EGAD00001001089	RNAseq BAM files for the Fat samples of the EUROBATS project	685

Publications	Citations
Genetic interactions affecting human gene expression identified by variance association mapping. Brown AA, Buil A, Viñuela A, Lappalainen T, Zheng HF, Richards JB, Small KS, Spector TD, Dermitzakis ET, Durbin R. Elife 3: 2014 e01381	90
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins. Buil A, Brown AA, Lappalainen T, Viñuela A, Davies MN, Zheng HF, Richards JB, Glass D, Small KS, Durbin R, Spector TD, Dermitzakis ET. Nat Genet 47: 2015 88-91	172
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression. Davies MN, Verdi S, Burri A, Trzaskowski M, Lee M, Hettema JM, Jansen R, Boomsma DI, Spector TD. PLoS One 10: 2015 e0134865	32
Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes. Glastonbury CA, Viñuela A, Buil A, Halldorsson GH, Thorleifsson G, Helgason H, Thorsteinsdottir U, Stefansson K, Dermitzakis ET, Spector TD, Small KS. Am J Hum Genet 99: 2016 567-579	26
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus. Odhams CA, Cortini A, Chen L, Roberts AL, Viñuela A, Buil A, Small KS, Dermitzakis ET, Morris DL, Vyse TJ, Cunninghame Graham DS. Hum Mol Genet 26: 2017 1003-1017	40
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort. Viñuela A, Brown AA, Buil A, Tsai PC, Davies MN, Bell JT, Dermitzakis ET, Spector TD, Small KS. Hum Mol Genet 27: 2018 732-741	85
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI. Nat Genet 50: 2018 572-580	125
Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue. Couto Alves A, Glastonbury CA, El-Sayed Moustafa JS, Small KS. BMC Genomics 19: 2018 659	9
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health. Tsai PC, Glastonbury CA, Eliot MN, Bollepalli S, Yet I, Castillo-Fernandez JE, Carnero-Montoro E, Hardiman T, Martin TC, Vickers A, Mangino M, Ward K, Pietiläinen KH, Deloukas P, Spector TD, Viñuela A, Loucks EB, Ollikainen M, Kelsey KT, Small KS, Bell JT. Clin Epigenetics 10: 2018 126	99
Epigenetic findings in periodontitis in UK twins: a cross-sectional study. Kurushima Y, Tsai PC, Castillo-Fernandez J, Couto Alves A, El-Sayed Moustafa JS, Le Roy C, Spector TD, Ide M, Hughes FJ, Small KS, Steves CJ, Bell JT. Clin Epigenetics 11: 2019 27	34
Nuclear genetic regulation of the human mitochondrial transcriptome. Ali AT, Boehme L, Carbajosa G, Seitan VC, Small KS, Hodgkinson A. Elife 8: 2019 e41927	53
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Odhams CA, Roberts AL, Vester SK, Duarte CST, Beales CT, Clarke AJ, Lindinger S, Daffern SJ, Zito A, Chen L, Jones LL, Boteva L, Morris DL, Small KS, Fernando MMA, Cunninghame Graham DS, Vyse TJ. Nat Commun 10: 2019 2164	82
Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age. Zito A, Davies MN, Tsai PC, Roberts S, Andres-Ejarque R, Nardone S, Bell JT, Wong CCY, Small KS. Nat Commun 10: 2019 5339	53
Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases. Martin TC, Šimurina M, Ząbczyńska M, Martinic Kavur M, Rydlewska M, Pezer M, Kozłowska K, Burri A, Vilaj M, Turek-Jabrocka R, Krnjajić-Tadijanović M, Trofimiuk-Müldner M, Ugrina I, Lityńska A, Hubalewska-Dydejczyk A, Trbojevic-Akmacic I, Lim EM, Walsh JP, Pocheć E, Spector TD, Wilson SG, Lauc G. Mol Cell Proteomics 19: 2020 774-792	33
Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes. Ali AT, Idaghdour Y, Hodgkinson A. Commun Biol 3: 2020 147	21
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating <i>Polg1</i> and mitochondrial remodeling. Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. Sci Transl Med 12: 2020 eaax8096	86
A compendium of uniformly processed human gene expression and splicing quantitative trait loci. Kerimov N, Hayhurst JD, Peikova K, Manning JR, Walter P, Kolberg L, Samoviča M, Sakthivel MP, Kuzmin I, Trevanion SJ, Burdett T, Jupp S, Parkinson H, Papatheodorou I, Yates AD, Zerbino DR, Alasoo K. Nat Genet 53: 2021 1290-1299	314
Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals. Hoskins JW, Chung CC, O'Brien A, Zhong J, Connelly K, Collins I, Shi J, Amundadottir LT. PLoS Comput Biol 17: 2021 e1009563	3
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19. El-Sayed Moustafa JS, Jackson AU, Brotman SM, Guan L, Villicaña S, Roberts AL, Zito A, Bonnycastle L, Erdos MR, Narisu N, Stringham HM, Welch R, Yan T, Lakka T, Parker S, Tuomilehto J, Seow J, Graham C, Huettner I, Acors S, Kouphou N, Wadge S, Duncan EL, Steves CJ, Doores KJ, Malim MH, Collins FS, Pajukanta P, Boehnke M, Koistinen HA, Laakso M, Falchi M, Bell JT, Scott LJ, Mohlke KL, Small KS. Int J Obes (Lond) 46: 2022 1478-1486	32
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers. Christiansen C, Tomlinson M, Eliot M, Nilsson E, Costeira R, Xia Y, Villicaña S, Mompeo O, Wells P, Castillo-Fernandez J, Potier L, Vohl MC, Tchernof A, Moustafa JE, Menni C, Steves CJ, Kelsey K, Ling C, Grundberg E, Small KS, Bell JT. Genome Med 14: 2022 75	10
Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable. Zito A, Roberts AL, Visconti A, Rossi N, Andres-Ejarque R, Nardone S, El-Sayed Moustafa JS, Falchi M, Small KS. PLoS Genet 19: 2023 e1010556	24
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome. Costeira R, Evangelista L, Wilson R, Yan X, Hellbach F, Sinke L, Christiansen C, Villicaña S, Masachs OM, Tsai PC, Mangino M, Menni C, Berry SE, Beekman M, van Heemst D, Slagboom PE, Heijmans BT, Suhre K, Kastenmüller G, Gieger C, Peters A, Small KS, Linseisen J, Waldenberger M, Bell JT. Clin Epigenetics 15: 2023 166	5
Genetic effects on the skin methylome in healthy older twins. Shore CJ, Villicaña S, El-Sayed Moustafa JS, Roberts AL, Gunn DA, Bataille V, Deloukas P, Spector TD, Small KS, Bell JT. Am J Hum Genet 111: 2024 1932-1952	2
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Fernandes Silva L, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ. Nat Genet 57: 2025 180-192	19
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity. Heikkinen A, Esser VFC, Lee SHT, Lundgren S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Heinonen S, Villicaña S, Bell JT, Maguolo A, Nilsson E, Ling C, Vaag A, Pajukanta P, Kaprio J, Pietiläinen KH, Li S, Ollikainen M. Nat Commun 16: 2025 4374	0
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus. Freimann K, Brümmer A, Warmerdam R, Rupall TS, Hernández-Ledesma AL, Chiou J, Holzinger ER, Maranville JC, Nakic N, Ongen H, Stefanucci L, Turchin MC, eQTLGen Consortium, Franke L, Võsa U, Jones CP, Medina-Rivera A, Trynka G, Kisand K, Bergmann S, Alasoo K. Nat Commun 16: 2025 8795	0