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RNA-seq data from the EUROBATS Project in four tissues: Fat, LCL, Skin and whole Blood.

EUROBATS consists of RNA-seq data for female twins in lisphoblastoide cell lines (LCL), abdominal adipose tissue (Fat), abdominal skin tissue (Skin) and whole blood (Blood). The samples are a combination of MZ twins, DZ twins and singletons. The goal of the project is to find biomarkers related with the ageing process and cellular senescence.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001086 765
EGAD00001001087 672
EGAD00001001088 391
EGAD00001001089 685
Publications Citations
Genetic interactions affecting human gene expression identified by variance association mapping.
Elife 3: 2014 e01381
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins.
Nat Genet 47: 2015 88-91
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.
PLoS One 10: 2015 e0134865
Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.
Am J Hum Genet 99: 2016 567-579
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus.
Hum Mol Genet 26: 2017 1003-1017
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort.
Hum Mol Genet 27: 2018 732-741
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Nat Genet 50: 2018 572-580
Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue.
BMC Genomics 19: 2018 659
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
Clin Epigenetics 10: 2018 126
Epigenetic findings in periodontitis in UK twins: a cross-sectional study.
Clin Epigenetics 11: 2019 27
Nuclear genetic regulation of the human mitochondrial transcriptome.
Elife 8: 2019 e41927
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Nat Commun 10: 2019 2164
Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.
Nat Commun 10: 2019 5339
Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.
Mol Cell Proteomics 19: 2020 774-792
Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes.
Commun Biol 3: 2020 147
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating <i>Polg1</i> and mitochondrial remodeling.
Sci Transl Med 12: 2020 eaax8096
A compendium of uniformly processed human gene expression and splicing quantitative trait loci.
Nat Genet 53: 2021 1290-1299
Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.
PLoS Comput Biol 17: 2021 e1009563
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
Int J Obes (Lond) 46: 2022 1478-1486
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.
Genome Med 14: 2022 75
Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable.
PLoS Genet 19: 2023 e1010556