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HipSci HumanExome BeadChip analysis-Healthy volunteers

The HipSci project brings together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. In this sub-study we performed Genotyping analysis using the Infinium HumanExome BeadChip on iPS cells generated from skin biopsies from healthy volunteers.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000566 120
EGAD00010000768 -
EGAD00010000773 Illumina 580
EGAD00010001147 Illumina 613
EGAD00010001328 Illumina -
Publications Citations
A Method for Checking Genomic Integrity in Cultured Cell Lines from SNP Genotyping Data.
PLoS One 11: 2016 e0155014
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.
Nat Genet 50: 2018 424-431
Genetic effects on promoter usage are highly context-specific and contribute to complex traits.
Elife 8: 2019 e41673
Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
Nat Genet 53: 2021 304-312
Optimizing expression quantitative trait locus mapping workflows for single-cell studies.
Genome Biol 22: 2021 188
A compendium of uniformly processed human gene expression and splicing quantitative trait loci.
Nat Genet 53: 2021 1290-1299
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation.
Cell Stem Cell 29: 2022 472-486.e7
Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells.
Mol Genet Genomics 297: 2022 1111-1122
Somatic mutations alter the differentiation outcomes of iPSC-derived neurons.
Cell Genom 3: 2023 100280