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Colorectal_organoids_and_tumour_tissue

Whole genome sequencing of single cell derived organoids from normal colon tissue and colorectal cancer.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001447 HiSeq X Ten 73
Publications Citations
Tissue-specific mutation accumulation in human adult stem cells during life.
Nature 538: 2016 260-264
490
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.
Science 358: 2017 234-238
215
The mutational impact of culturing human pluripotent and adult stem cells.
Nat Commun 11: 2020 2493
50
Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells <i>in vivo</i>.
iScience 25: 2022 103736
4
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue.
Nat Commun 13: 2022 5915
4
Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells.
iScience 25: 2022 105610
1