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Succession Of Transiently Active Tumour-Initiating Cell Clones inHuman Pancreatic Cancer

To elucidate whether newly acquired genetic alterations during serial transplantation of patient derived primary pancreatic cancer cultures contribute to the observed clonal dynamics in vivo, all coding genes of two patient derived primary cultures and derived genetically marked serial xenografts (1°/2°/3°) were sequenced.

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Dataset ID Description Technology Samples
EGAD00001000884 Illumina HiSeq 2000 10
Publications Citations
Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts.
EMBO Mol Med 9: 2017 918-932