Study

Multisite Primary Breast Cancer

Study ID Alternative Stable ID Type
EGAS00001000891 Cancer Genomics

Study Description

DNA extracted from multiple biopsies taken from different areas of primary breast tumours will be subjected to targeted re-sequencing and analysed in order to assess intra-tumour heterogeneity with respect to mutations in a selection of cancer related genes.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001000965
Cancers are ecosystems of genetically related clones, competing across space and time for limited resources. To understand the clonal structure of primary breast cancer, we applied genome and targeted sequencing to 295 samples from 49 patients’ tumors. The extent of subclonal diversification varied considerably among patients and encompassed many spatial patterns, including local growth, intraductal dissemination and clonal intermixture. Landmarks of disease progression, such as acquiring ... (Show More)
Illumina HiSeq 2000 331

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