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DNA methylation repeatability in the Lothian Birth Cohorts of 1921 and 1936.

The repeatability of longitudinal measures of whole blood DNA methylation (obtained using the Illumina 450k chip) was assessed in two cohorts of ageing. The Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936. Data were collected at ages 70, 73, and 76 (LBC1936) and 79, 87, 90 (LBC1921) with 478 participants having two or more measures of methylation.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000604 2195
Publications Citations
Genetic and environmental exposures constrain epigenetic drift over the human life course.
Genome Res 24: 2014 1725-1733
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.
Int J Epidemiol 44: 2015 1388-1396
DNA methylation age of blood predicts all-cause mortality in later life.
Genome Biol 16: 2015 25
Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations.
Am J Hum Genet 97: 2015 75-85
DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy.
Aging (Albany NY) 8: 2016 394-401
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
Genome Biol 17: 2016 255
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.
PLoS Med 14: 2017 e1002215
Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis.
Sci Rep 7: 2017 8183
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
PLoS One 12: 2017 e0182472
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Nat Commun 9: 2018 387
Genotype effects contribute to variation in longitudinal methylome patterns in older people.
Genome Med 10: 2018 75
Identification of 55,000 Replicated DNA Methylation QTL.
Sci Rep 8: 2018 17605
DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns.
Clin Epigenetics 11: 2019 23
Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait.
Genetics 212: 2019 577-586
OSCA: a tool for omic-data-based complex trait analysis.
Genome Biol 20: 2019 107
Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples.
Genome Med 12: 2020 39
Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality.
Circ Genom Precis Med 13: 2020 e002766
Integrative analysis of clinical and epigenetic biomarkers of mortality.
Aging Cell 21: 2022 e13608
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression.
Hum Mol Genet 32: 2023 1912-1921