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Genotyping_of_additional_Inflammatory_Bowel_Disease_cases___2014

Both internal and external funding has enabled 5000 inflammatory bowel disease cases to be whole genome sequenced (CD @4X, UC @2X). The Anderson and Barrett groups are currently generating genotypes across these samples for comparison to 4000 population controls sequenced as part of UK10K. The UK10K project has shown that imputing sequenced genetic variation into previously GWASed samples greatly increases power to detect association. Given that our study has been designed to detect association to low frequency variation (0.5% and above) these gains in power are especially important. Overall, the UKIBDGC has GWAS data for around 1800 CD samples (Affy 500K) and 3000 UC samples (Affy6), though some of these samples have also been whole genome sequenced. Here, we apply to get all remaining non-GWAS and non-WGS IBD cases in the UKIBDGC (N=X) genotyped genotyped on the Illumina Core Exome Array

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001157 Illumina Human Core Exome 12v1-1_a 9247
EGAD00010001158 Illumina Human Core Exome 12v1-1_a 11767
Publications Citations
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
Nat Genet 49: 2017 256-261
591
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.
Nat Genet 49: 2017 186-192
88
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
Nat Commun 11: 2020 995
24
Assessment of Causal Direction Between Gut Microbiota and Inflammatory Bowel Disease: A Mendelian Randomization Analysis.
Front Genet 12: 2021 631061
17
shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores.
Am J Hum Genet 111: 2024 1006-1017
0