Study

Frequent alterations in cytoskeleton remodeling genes in primary and metastatic Chinese lung adenocarcinomas

Study ID Alternative Stable ID Type
EGAS00001000982 Other

Study Description

The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including themost commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scalesequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
EGAD00001001397
We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.
Illumina HiSeq 2000 72
EGAD00001001398
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
Illumina HiSeq 2000 147

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