Study

Genotype data of osteoarthritis cases from the UK collected by the arcOGEN Consortium (http://www.arcogen.org.uk/).

Study ID Alternative Stable ID Type
EGAS00001001017 Other

Study Description

The arcOGEN study is a UK-wide collaboration effort by the Arthritis Research UK Osteoarthritis Genetics (arcOGEN) Consortium (http://www.arcogen.org.uk/) aimed at the identification of the genetic determinants of osteoarthritis (OA). Unrelated samples were collected in 2 stages from 10 United Kingdom locations (London, Nottingham, Oxford, Sheffield, Southampton, Edinburgh, Newcastle-Upon-Tyne, Sheffield, Wansbeck, and Worcester). The majority of cases had primary OA requiring joint replacement of the hip or knee while a smaller number were ascertained by radiographic evidence of disease (Kellgren-Lawrence (KL) grade ≥2). The exclusion criteria included the need for joint replacement due to fracture, secondary OA of any cause, and developmental, vascular, or infective causes of joint disease. The full genotype data generated from the arcOGEN genome-wide association scan (GWAS) is contained in separate datasets because of differences in patient consent between the different collection sites.

Study Datasets 9 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000740
Osteoarthritis cases genotyped on Illumina HumanOmniExpress from the arcOGEN Consortium (http://www.arcogen.org.uk/) with broader consent.
674
EGAD00010000742
Subset 1 of osteoarthritis cases genotyped on Illumina610k from the arcOGEN Consortium (http://www.arcogen.org.uk/) with broader consent.
5383
EGAD00010000744
Subset 2 of osteoarthritis cases genotyped on Illumina 610k from the arcOGEN Consortium (http://www.arcogen.org.uk/) with consent for osteoarthritis studies only.
2326
EGAD00010000922
Subset 1 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-24v1-0 with broader consent.
Illumina HumanCoreExome-24v1-0 494
EGAD00010000923
Subset 2 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-12v1-0 with consent for osteoarthritis studies only.
Illumina HumanCoreExome-12v1-0 463
EGAD00010000924
Subset 2 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-12v1-1 with consent for osteoarthritis studies only.
Illumina HumanCoreExome-12v1-1 991
EGAD00010000925
Subset 1 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-12v1-0 with broader consent.
Illumina HumanCoreExome-12v1-0 855
EGAD00010000926
Subset 1 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-12v1-1 with broader consent.
Illumina HumanCoreExome-12v1-1 3075
EGAD00010000927
Subset 2 of osteoarthritis cases from the arcOGEN Consortium (http://www.arcogen.org.uk/) genotyped on HumanCoreExome-24v1-0 with consent for osteoarthritis studies only.
Illumina HumanCoreExome-24v1-0 248

Who archives the data?

Publications

Citations

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