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Follow_up_for_second_tier_signals_from_the_arcOGEN_GWAS

The arcOGEN UK nationwide consortium has been funded by the arc to undertake a genome-wide association scan in osteoarthritis. GWA genotyping has been carried out at the Sanger on the illumina 610k array. This replication study was desinged to follow-up second-tier signals from the arcOGEN GWS in 25 SNPs (1Sequenom iPLEX) with p<5x10^-6 on 6000 additional UK OA and control samples.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000740 674
EGAD00010000742 5383
EGAD00010000744 2326
EGAD00010000922 Illumina HumanCoreExome-24v1-0 494
EGAD00010000923 Illumina HumanCoreExome-12v1-0 463
EGAD00010000924 Illumina HumanCoreExome-12v1-1 991
EGAD00010000925 Illumina HumanCoreExome-12v1-0 855
EGAD00010000926 Illumina HumanCoreExome-12v1-1 3075
EGAD00010000927 Illumina HumanCoreExome-24v1-0 248
Publications Citations
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
Lancet 380: 2012 815-823
281
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
Ann Rheum Dis 73: 2014 2130-2136
84
Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene.
Eur J Hum Genet 25: 2017 446-451
38
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
Am J Hum Genet 100: 2017 865-884
122
A novel variant in <i>GLIS3</i> is associated with osteoarthritis.
Ann Rheum Dis 77: 2018 620-623
21
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Nat Genet 51: 2019 230-236
315
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
Cell 184: 2021 4784-4818.e17
212