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English Longitudinal Study of Ageing Genome-wide genotyping using the Illumina HumanOmni2.5-8

These data are for a Genome Wide Association Study (GWAS) in the English Longitudinal Study of Ageing (ELSA, www.ifs.org.uk/elsa), building on the existing ELSA DNA Repository (EDNAR). This will establish a valuable resource for UK and international scientists, giving them access to GWAS genotyping data. Phenotype data, available on request, includes measures of personality, attitudes, behaviours as well as detailed social and economic outcomes; high quality biomarkers and other intermediate phenotypes; a range of more distal phenotypes, such as direct assessments of health (for example, hypertension, diabetes, muscle strength and cognitive function), and the opportunity to analyse existing biological samples for additional biomarkers, including metabolomic studies. Importantly, this resource would be matched with a near identical resource established in the United States for the Health and Retirement Study (HRS), giving the potential for high quality replication studies and comparative analyses.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000674 7412
EGAD00010000676 7452
Publications Citations
Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom.
J Psychiatr Res 100: 2018 63-70
3
Frailty Index associates with GRIN2B in two representative samples from the United States and the United Kingdom.
PLoS One 13: 2018 e0207824
9
GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank.
Am J Hum Genet 105: 2019 788-802
53