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Genome-wide SNP genotyping and DNA methylation epigenotyping of African rainforest hunter-gatherers and neighbouring agriculturalists

The epigenomic landscape of the human genome, in particular DNA methylation, is increasingly recognised as an important driver of phenotypic diversity in health and disease. However, the impact that genetic variation and changes in lifestyle and ecological habitat have on this epigenetic mark remains unknown. To address this question, we analysed genome-wide SNP and DNA methylation profiles of 362 individuals from African populations of rainforest hunter-gatherers and sedentary farmers with different past and present lifestyles and ecologies.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000690 160
EGAD00010000692 372
Publications Citations
The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Nat Commun 6: 2015 10047
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Genome Biol 17: 2016 171
Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.
Genetics 206: 2017 1659-1674