Study
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Study ID | Alternative Stable ID | Type |
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EGAS00001001085 | Other |
Study Description
Multiple regulatory elements distant to their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we have developed a capture Hi-C (cHi-C) approach to allow an agnostic characterisation of these physical interactions on a genome-wide scale. Single nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci has allowed us to identify key long-range chromatin interactions in cis and trans involving these loci.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00001001243 |
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
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Illumina HiSeq 2000 | 9 |
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