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Genome-wide association analysis on five isolated populations - Erasmus Rucphen Family (ERF) Study

ERF is embedded in the Genetic Research in Isolated Population (GRIP) program. Genealogy of GRIP is available from its founding (1600-1650). For ERF, we selected 22 related (first and second degree, non-consanguineous) couples living in GRIP between 1850-1900, and having at least six children baptized in the community church. All living descendants of those couples were invited to participate in ERF1. About 4,000 relatives included in the study form a very complex pedigree, which consists of more than 23,000 members. The participants aged between 18-20 years constitute a unique single family spanning over 23 generations. Around 3,000 individuals have been extensively phenotyped for several psychiatric and somatic traits. All phenotyped individuals are genotyped on genome-wide genotyping arrays.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003571 3658
Publications Citations
Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.
Eur J Hum Genet 23: 2015 1717-1722
Prediction of male-pattern baldness from genotypes.
Eur J Hum Genet 24: 2016 895-902
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Nat Neurosci 19: 2016 1569-1582
A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants.
Front Genet 9: 2018 133
Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness.
Front Genet 9: 2018 420