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BLUEPRINT DNA methylation profiling of B-cell differentiation using Illumina HumanMethylation 450K BeadArray

We performed DNA methylation analysis in 6 different mature B-cell subpopulations using the Illumina HumanMethylation 450K BeadArray. In particular, we analyzed naive B cells from peripheral blood (naiBC); naive B cells from tonsil (t-naiBC); germinal center B cells (gcBC); plasma cells from tonsil (t-PC); memory B cells from peripheral blood (memBC) and plasma cells from bone marrow (bm-PC). All the samples were isolated from healthy donors and we analyzed 3 to 9 biological replicates of each subtype.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000716 35
Publications Citations
Whole-genome fingerprint of the DNA methylome during human B cell differentiation.
Nat Genet 47: 2015 746-756
Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies.
Epigenomics 8: 2016 1185-1192
Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy.
Blood Cancer Discov 2: 2021 54-69
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.
Nat Cancer 1: 2020 1066-1081