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Genomic Epidemiology of Complex Diseases in Population-based Brazilian Cohorts

The EPIGEN-Brasil Initiative is so far the largest Latin American initiative in population genomics and genetic epidemiology. Its main goal is to study the association between genetic variants found in the Brazilian population and complex diseases, taking into account one of the most important characteristics of this population: its admixture. Population genetic include genomewide genotyping of 6487 individuals and high-resolution whole genome sequencing from 30 individuals from three population-based Brazilian cohorts: Salvador, Bambuí and Pelotas. More information about the population-based cohorts are available on: For the 1982 Pelotas birth cohort study in Victora and Barros 2006 (PMID 16373375); For the Bambui cohort study of aging in LIma-Costa MF et al. (2011) (PMID 20805109); For the Salvador-Scaala study in Barreto et al. (2006) (PMID 16796729)

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000787 6487
Publications Citations
Cohort profile: the Bambui (Brazil) Cohort Study of Ageing.
Int J Epidemiol 40: 2011 862-867
Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.
Proc Natl Acad Sci U S A 112: 2015 8696-8701
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set.
Eur J Hum Genet 24: 2016 725-731
Genomic Ancestry, Self-Rated Health and Its Association with Mortality in an Admixed Population: 10 Year Follow-Up of the Bambui-Epigen (Brazil) Cohort Study of Ageing.
PLoS One 10: 2015 e0144456
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging.
PLoS Negl Trop Dis 10: 2016 e0004724
Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children.
Eur J Hum Genet 25: 2017 439-445
Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.
Sci Rep 9: 2019 18085
Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas.
Mol Biol Evol 37: 2020 1647-1656
<i>WSB1</i> and <i>IL21R</i> Genetic Variants Are Involved in Th2 Immune Responses to <i>Ascaris lumbricoides</i>.
Front Immunol 12: 2021 622051
<i>LRRK2</i> Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations.
Front Psychiatry 12: 2021 665257