Study

DNA methylation and somatic mutations converge on cell cycle and define similar evolutionary histories in brain tumors

Study ID Alternative Stable ID Type
EGAS00001001255 Other

Study Description

The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to the stability of genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question whether epigenetics can be similarly used to discover tumor phylogeny. We examined the spatial and temporal dynamics of DNA methylation in a cohort of low-grade gliomas and their patient-matched recurrences. Genes upregulated through promoter hypomethylation during malignant progression to high-grade glioblastoma were enriched in cell cycle function, evolving in parallel with genetic alterations that deregulate the G1/S cell cycle checkpoint. Moreover, phyloepigenetic relationships robustly recapitulated phylogenetic patterns inferred from somatic mutations. These findings highlight widespread co-dependency of genetic and epigenetic events throughout brain tumor evolution.

Study Datasets 6 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001613
NA
10
EGAD00001001614
NA
26
EGAD00001001615
NA
10
EGAD00001001616
NA
2
EGAD00010000827
Illumina Infinium 450K array data
1
EGAD00010000829
Illumina Infinium 450K array data
70

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