Novel Epigenetic Markers for Toxicity after Intraoperative and Conventional Radiotherapy for Breast Cancer

Study ID Alternative Stable ID Type
EGAS00001001279 Other

Study Description

Ionizing radiation is a common treatment option for cancer but its use is limited by the unpredictable and highly heterogeneous onset of late side effects, especially radiation-induced fibrosis. Clinically applicable biomarkers and effective treatments for radiation fibrosis are currently unavailable. In order to identify novel markers we ran a genome-wide DNA methylation screen in primary dermal fibroblasts obtained from breast cancer patients before intraoperative radiotherapy. Cells from patients developing fibrosis within a three-year follow up were compared to those without fibrosis (12 individuals per group). Illumina Infinium HumanMethylation450 BeadChip Technology was used.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
Control human dermal fibroblasts from patient forearm
Illumina 450k 12
Case human dermal fibroblasts from patient forearm
Illumina 450k 12

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