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Integrated molecular analysis of adult T-cell leukemia/lymphoma

This study is an integrated molecular study of adult T-cell leukemia/lymphoma which includes whole-exome (n = 81), whole-genome (n = 48), and transcriptome sequencing data (n = 57) as well as methylation (n = 109) and SNP array data (n = 426)

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001410 Illumina HiSeq 2000 162
EGAD00001001411 Illumina HiSeq 2000 63
EGAD00001001412 HiSeq X Ten Illumina HiSeq 2000 96
EGAD00010000811 1
EGAD00010000813 1
EGAD00010000815 1
Publications Citations
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.
Blood 131: 2018 215-225
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Nature 552: 2017 121-125
Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma.
Neoplasia 20: 2018 883-893
RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma.
NPJ Genom Med 4: 2019 10
Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1.
Nat Commun 11: 2020 3045
CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.
Commun Biol 5: 2022 1309