Comprehensive analysis of the (epi)genome of pediatric atypical teratoid/rhabdoid tumours (AT/RTs)
Whole exome sequencing of atypical teratoid /rhabdoid tumors (AT/RTs) revealed recurrent mutations only in SMARCB1, a gene involved in chromatin remodeling. However, preliminary data from our lab using gene expression and DNA methylation arrays shows that there are three distinct molecular subgroups of AT/RTs, suggesting that other molecular alterations underlying the development of these aggressive pediatric brain tumors must be found outside the coding genome or at the epigenomic level. Identification of these (epi)genomic alterations, which we intend to address in this project, may lead to novel treatment strategies for these tumors and reveal options for meaningful patient stratification.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001001444||Illumina HiSeq 2000 Illumina HiSeq 2500||55|
|EGAD00001002135||Illumina HiSeq 2000 Illumina HiSeq 2500||15|
|EGAD00001002136||Illumina HiSeq 2000||25|
|EGAD00001002137||Illumina HiSeq 2000 Illumina HiSeq 2500||15|
|EGAD00001002138||Illumina HiSeq 2000||36|
|EGAD00001003408||Illumina HiSeq 2000||19|
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