Study

Comprehensive analysis of the (epi)genome of pediatric atypical teratoid/rhabdoid tumours (AT/RTs)

Study ID Alternative Stable ID Type
EGAS00001001297 Other

Study Description

Whole exome sequencing of atypical teratoid /rhabdoid tumors (AT/RTs) revealed recurrent mutations only in SMARCB1, a gene involved in chromatin remodeling. However, preliminary data from our lab using gene expression and DNA methylation arrays shows that there are three distinct molecular subgroups of AT/RTs, suggesting that other molecular alterations underlying the development of these aggressive pediatric brain tumors must be found outside the coding genome or at the epigenomic level. Identification of these (epi)genomic alterations, which we intend to address in this project, may lead to novel treatment strategies for these tumors and reveal options for meaningful patient stratification.

Study Datasets 6 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001444
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants and young children. Although the prognosis of ATRT patients is poor, some patients respond very well to current treatments, suggesting inter-tumor molecular heterogeneity. To investigate this further, we genetically and epigenetically analyzed a large cohort of ATRTs (n = 170). Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location and type of SMARCB1 ... (Show More)
Illumina HiSeq 2000,Illumina HiSeq 2500 55
EGAD00001002135
ChIPseq data of Atypical teratoid/rhabdoid tumors (ATRT)
Illumina HiSeq 2000,Illumina HiSeq 2500 15
EGAD00001002136
RNA sequencing data of Atypical teratoid/rhabdoid tumors (ATRT)
Illumina HiSeq 2000 25
EGAD00001002137
WGBS data of Atypical teratoid/rhabdoid tumors (ATRT)
Illumina HiSeq 2000,Illumina HiSeq 2500 15
EGAD00001002138
WGS data of Atypical teratoid/rhabdoid tumors (ATRT)
Illumina HiSeq 2000 36
EGAD00001003408
Chip-Seq sequencing data of Atypical teratoid/rhabdoid tumors (ATRT)
Illumina HiSeq 2000 19

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