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Carcinoma of the oral tongue (OTSCC) genomic landscape characterisation

Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001465 Illumina HiSeq 2000 127
Publications Citations
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.
Genome Med 7: 2015 98
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
Nat Commun 11: 2020 5671