Melanoma_multi_site_metastases

Despite multiple large-scale sequencing studies offering substantial insight into the genomic landscape of cutaneous melanoma, the molecular events surrounding disease progression and the resulting molecular heterogeneity between metastases have not been fully elucidated. We have been applying whole genome and transcriptome sequencing across metastases collected during post mortem as well as to multi-site metastases during treatment

Type: Cancer Genomics
Archiver: EGA European Genome-Phenome Archive

4 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001005072	We have been applying whole genome and transcriptome sequencing across metastases collected during post mortem. Herein we show the findings for the first such patient.	HiSeq X Ten	14
EGAD00001005421	These are 21 metastatic melanoma exomes matched with 7 germlines from 7 multisite metastatic melanoma cases.	Illumina HiSeq 2000	28
EGAD00001005483	These are caveman, pindel, battenberg and brass calls for index patients' metastatic melanoma genomes within this study.		13
EGAD00001005487	These are caveman, pindel and sequenza calls for the metastatic melanoma exomes within this study.		19

Publications	Citations
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases. Rabbie R, Ansari-Pour N, Cast O, Lau D, Scott F, Welsh SJ, Parkinson C, Khoja L, Moore L, Tullett M, Wong K, Ferreira I, Gómez JMM, Levesque M, Gallagher FA, Jiménez-Sánchez A, Riva L, Miller ML, Allinson K, Campbell PJ, Corrie P, Wedge DC, Adams DJ. Nat Commun 11: 2020 4306	17