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Fixative optimisation study for BRITROC project

The British Translational Research Ovarian Cancer Collaborative (BriTROC), spanning more than 10 centres across UK, is a prospective observational project focused on relapsed high-grade serous ovarian cancer (HGSOC). The first study, as a part of the project, is the Fixative optimisation study, which analyses the utility for next-generation sequencing of UMFIX samples compared to NBF-fixed and fresh frozen samples. Various DNA and sequencing quality analyses were performed to compare fixation methods in bulk tumour and biopsy samples.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001937 Illumina MiSeq 66
EGAD00001001938 Illumina HiSeq 2500 60
Publications Citations
Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples.
Ann Oncol 27: 2016 532-539