Need Help?

T2D-GENES: Exome sequencing

The Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) is a large collaboration effort between the University of Michigan, Broad Institute, the Wellcome Trust Centre for Human Genetics, University of Chicago, NIDDK, Texas Biomedical Research Institute, University of Texas Health Science Center, University of North Carolina, Blood Systems Research Institute, and University of Mississippi Medical Center. The goal of this study is to identify genetic variants for type 2 diabetes through multiethnic sequencing studies. In this study, we use next generation sequencing to assess the role of common, low frequency, and rare variants on type 2 diabetes risk. We preformed exome sequencing in 6,546 T2D cases and 6,457 control individuals of multiethnic origin, including individuals of African American, East Asian, South Asian, Hispanic, and European descent.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002246 13007
EGAD00010001187 -
EGAD00010001188 -
Publications Citations
The genetic architecture of type 2 diabetes.
Nature 536: 2016 41-47
585
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Sci Data 4: 2017 170179
19
Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.
PLoS One 13: 2018 e0199837
6