Inherited damaging mutations in immune-related genes favour the development of genetically heterogeneous synchronous colorectal cancer.

Study

Study ID	Alternative Stable ID	Type
EGAS00001001461		Other

Study Description

Synchronous colorectal cancers are physically separated tumours that develop simultaneously in the intestine. To understand how common genetic and environmental backgrounds influence the development of multiple tumours, we conduct a genome-wide comparative analysis of somatic alterations of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire discordant somatic alterations, and follow different clonal developments.

Study Datasets 3 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001001608	Aligned BAM files of whole exome sequencing of 20 syCRCs and 10 normal counterparts. Each sample of 4 patients (S13, S3, S12 and S6) underwent two sequencing rounds. Aligned BAM files of whole exome sequencing of 20 syCRCs and 10 normal counterparts. Each sample of 4 patients (S13, S3, S12 and S6) underwent two sequencing rounds.	Illumina HiSeq 2000,Illumina HiSeq 2500	42
EGAD00001001870	Deep sequencing of 151 cancer genes in 6 synchronous CRC of 3 patients Deep sequencing of 151 cancer genes in 6 synchronous CRC of 3 patients	Illumina MiSeq	6
EGAD00010000823	Results of SNP arrays on synchronous CRC samples Results of SNP arrays on synchronous CRC samples		1

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