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Inherited damaging mutations in immune-related genes favour the development of genetically heterogeneous synchronous colorectal cancer.

Synchronous colorectal cancers are physically separated tumours that develop simultaneously in the intestine. To understand how common genetic and environmental backgrounds influence the development of multiple tumours, we conduct a genome-wide comparative analysis of somatic alterations of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire discordant somatic alterations, and follow different clonal developments.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001608 Illumina HiSeq 2000 Illumina HiSeq 2500 42
EGAD00001001870 Illumina MiSeq 6
EGAD00010000823 1
Publications Citations
Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.
Nat Commun 7: 2016 12072