Study

HipSci - Human Induced Pluripotent Stem Cells Initiative

Study ID Alternative Stable ID Type
EGAS00001001465 Other

Study Description

Human induced pluripotent stem (iPS) cells can be generated from adult tissues and differentiated into a range of specific cell types (Yamanaka and Blau, 2010). They therefore provide unprecedented opportunities for investigating disease mechanisms and understanding the phenotypic consequences of genetic variation within the normal population. HipSci brings together diverse constitutents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. Between 2013 and 2016 we aim to generate iPS cells from over 500 healthy individuals and 500 individuals with genetic disease. We will then use these cells to discover how genomic variation impacts on cellular phenotype and identify new disease mechanisms. Strong links with NHS investigators will ensure that studies on the disease-associated cell lines will be linked to extensive clinical information. Further key features of the project are an open access model of data sharing; engagement of the wider clinical genetics community in selecting ... (Show More)

Study Datasets 5 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000564
HipSci - Healthy Normals - Expression Array - May 2014
120
EGAD00010000566
HipSci - Healthy Normals - Genotyping Array - May 2014
120
EGAD00010000568
HipSci - Healthy Normals - Methylation Array - May 2014
N/A
EGAD00010000768
Replication data for HipSci normal samples using both HumanCoreExome-12_v1 and HumanOmni2.5-8 BeadChips
N/A
EGAD00010000771
HipSci - Healthy Normals - Methylation Array - April 2015
N/A

Who archives the data?

Publications

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