Sequencing of serial plasma and multiregional tumor samples in a patient with metastatic breast cancer

Study ID Alternative Stable ID Type
EGAS00001001466 Other

Study Description

Circulating tumor DNA analysis can be used to track tumor burden and analyze cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here, we follow a patient with metastatic ER and HER2 positive breast cancer receiving two lines of targeted therapy over 3 years. We characterize genomic architecture and infer clonal evolution in 8 tumor biopsies and 9 plasma samples collected over 1,193 days of clinical follow-up using exome and targeted amplicon sequencing.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Exome and targeted amplicon sequencing data for tumor, germline and plasma samples from a patient with metastatic breast cancer.
Illumina HiSeq 2500,Illumina MiSeq 30

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