Study

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Study ID Alternative Stable ID Type
EGAS00001001501 Other

Study Description

DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism/Seckel syndrome. We establish that TRAIP relocalizes to sites of DNA damage where it is required for optimal phosphorylation of H2AX and RPA2 during S-phase in response to UV irradiation, as well as fork progression through UV-induced DNA lesions. TRAIP is necessary for efficient cell cycle progression and mutations in TRAIP therefore limit cellular proliferation, providing a potential mechanism for microcephaly and dwarfism phenotypes. Human genetics thus identifies TRAIP as a novel component of the DNA damage response to replication-blocking DNA lesions.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001001633
BAM files for two WES TRAIP patients
Illumina HiSeq 2000 2

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