Genetic landscape of relapsed DLBCL
Diffuse large B-cell lymphoma is a heterogenous malignancy that can arise de novo or can result from histologic transformation from indolent lymphomas. Considerable sequencing effort has been placed on determining the mutations that are common at the time of diagnosis in DLBCL but little is known about the nature of relapsed disease. We have sequenced tumour and matched normal exomes of 38 rrDLBCL patients including 25 de novo DLBCLs and 13 transformed lymphomas to identify somatic mutations and copy number alterations associated with relapse.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.
Clin Cancer Res 22: 2016 2290-2300