Study

Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015

Study ID Alternative Stable ID Type
EGAS00001001570 Other

Study Description

The transforming growth factor beta (TGFβ) signalling pathway exerts opposing effects on cancer cells, acting either as a tumor-promoter or as a tumor-suppressor. Here we show these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGFβ signalling, and the distinct epigenomes of breast tumor initiating cells (BTICs). These effects of TGFβ are associated with distinct gene expression programs, but genomic SMAD3 binding patterns are highly similar in the BTIC-promoting and BTIC- suppressing contexts. Our data show cell type-specific epigenetic configurations provide a modulatory layer by determining accessibility of genes to regulation by TGFβ/SMAD3. LBH, one such context-specific target gene, is regulated according to its DNA methylation status, and is crucial for TGFβ-dependent promotion of BTICs. Overall, these results reveal that the epigenome plays a central and previously overlooked role in shaping the context-specific effects of TGFβ in cancer.

Study Datasets 10 datasets.

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Dataset ID Description Technology Samples
EGAD00001001667
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
Illumina MiSeq 12
EGAD00001001668
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
Illumina HiSeq 2500 12
EGAD00001001669
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
Illumina HiSeq 2500 42
EGAD00010000859
Smad3
Illumina ChIP-Sequencing 16
EGAD00010000860
Pol2
Illumina ChIP-Sequencing 16
EGAD00010000862
H3K27me3
Illumina ChIP-Sequencing 16
EGAD00010000863
H3K27Ac
Illumina ChIP-Sequencing 16
EGAD00010000865
MBDSEQ
Illumina MBD-Sequencing 16
EGAD00010000867
Expression Arrays
Illumina beadarray 16
EGAD00010000868
Targeted bisulfite sequencing
Illumina Bisulfite-Sequencing 16

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