Study
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001001570 | Other |
Study Description
The transforming growth factor beta (TGFβ) signalling pathway exerts opposing effects on cancer cells, acting either as a tumor-promoter or as a tumor-suppressor. Here we show these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGFβ signalling, and the distinct epigenomes of breast tumor initiating cells (BTICs). These effects of TGFβ are associated with distinct gene expression programs, but genomic SMAD3 binding patterns are highly similar in the BTIC-promoting and BTIC- suppressing contexts. Our data show cell type-specific epigenetic configurations provide a modulatory layer by determining accessibility of genes to regulation by TGFβ/SMAD3. LBH, one such context-specific target gene, is regulated according to its DNA methylation status, and is crucial for TGFβ-dependent promotion of BTICs. Overall, these results reveal that the epigenome plays a central and previously overlooked role in shaping the context-specific effects of TGFβ in cancer.
Study Datasets 10 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001001667 |
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
|
Illumina MiSeq | 12 |
EGAD00001001668 |
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
|
Illumina HiSeq 2500 | 12 |
EGAD00001001669 |
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
|
Illumina HiSeq 2500 | 42 |
EGAD00010000859 |
Smad3
|
Illumina ChIP-Sequencing | 16 |
EGAD00010000860 |
Pol2
|
Illumina ChIP-Sequencing | 16 |
EGAD00010000862 |
H3K27me3
|
Illumina ChIP-Sequencing | 16 |
EGAD00010000863 |
H3K27Ac
|
Illumina ChIP-Sequencing | 16 |
EGAD00010000865 |
MBDSEQ
|
Illumina MBD-Sequencing | 16 |
EGAD00010000867 |
Expression Arrays
|
Illumina beadarray | 16 |
EGAD00010000868 |
Targeted bisulfite sequencing
|
Illumina Bisulfite-Sequencing | 16 |
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