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Isolated populations have unique population genetics characteristics that can help boost power in genetic association studies for complex traits. Leveraging these advantageous characteristics requires an in-depth understanding of parameters that have shaped sequence variation in isolates. This study performs a comprehensive investigation of these parameters using low-depth whole genome sequencing (WGS) across multiple isolates.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002014 6840
Publications Citations
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.
Nat Commun 8: 2017 15927
Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection.
Eur J Hum Genet 26: 2018 1167-1179
Hearing Function: Identification of New Candidate Genes Further Explaining the Complexity of This Sensory Ability.
Genes (Basel) 12: 2021 1228
Genetic Dissection of Temperament Personality Traits in Italian Isolates.
Genes (Basel) 13: 2021 4
Regulator of G-Protein Signalling 9: A New Candidate Gene for Sweet Food Liking?
Foods 12: 2023 1739
Clenching the Strings of Bruxism Etiopathogenesis: Association Analyses on Genetics and Environmental Risk Factors in a Deeply Characterized Italian Cohort.
Biomedicines 12: 2024 304