Study

Targeted sequencing of brain expressed miRNA genes

Study ID Alternative Stable ID Type
EGAS00001001607 Other

Study Description

As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes by screening 289 brain expressed miRNAs. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells.

Study Datasets 4 datasets.

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Dataset ID Description Technology Samples
EGAD00001001849
The genomic sequence of brain expressed miRNA genes was sequenced in Swedish schizophrenia patients
Illumina MiSeq 186
EGAD00001001850
Genomic DNA from Swedish control individuals was pooled. Then the genomic sequence of brain expressed miRNA genes was determined in the pools.
Illumina MiSeq 149
EGAD00001001851
The genomic sequence of brain expressed miRNA genes was sequenced in Belgian epilepsy patients.
Illumina MiSeq 163
EGAD00001001852
Genomic DNA from Belgian control individuals was pooled. Then the genomic sequence of brain expressed miRNA genes was determined in the pools.
Illumina MiSeq 39

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