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Targeted sequencing of brain expressed miRNA genes

As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes by screening 289 brain expressed miRNAs. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001849 Illumina MiSeq 186
EGAD00001001850 Illumina MiSeq 149
EGAD00001001851 Illumina MiSeq 163
EGAD00001001852 Illumina MiSeq 39
Publications Citations
Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets.
PLoS One 10: 2015 e0144428