Targeted sequencing of brain expressed miRNA genes

As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes by screening 289 brain expressed miRNAs. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells.

Type: Other
Archiver: EGA European Genome-Phenome Archive

4 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001001849	The genomic sequence of brain expressed miRNA genes was sequenced in Swedish schizophrenia patients	Illumina MiSeq	186
EGAD00001001850	Genomic DNA from Swedish control individuals was pooled. Then the genomic sequence of brain expressed miRNA genes was determined in the pools.	Illumina MiSeq	149
EGAD00001001851	The genomic sequence of brain expressed miRNA genes was sequenced in Belgian epilepsy patients.	Illumina MiSeq	163
EGAD00001001852	Genomic DNA from Belgian control individuals was pooled. Then the genomic sequence of brain expressed miRNA genes was determined in the pools.	Illumina MiSeq	39

Publications	Citations
Schizophrenia-Associated MIR204 Regulates Noncoding RNAs and Affects Neurotransmitter and Ion Channel Gene Sets. Cammaerts S, Strazisar M, Smets B, Weckhuysen S, Nordin A, De Jonghe P, Adolfsson R, De Rijk P, Del Favero J. PLoS One 10: 2015 e0144428	6