Study
BLUEPRINT DNA Methylation 450K data of mantle cell lymphoma
Study ID | Alternative Stable ID | Type |
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EGAS00001001637 | Other |
Study Description
We have applied an analytic strategy to decipher the DNA methylome of 86 mantle cell lymphomas (MCL) in light of the methylome of the entire B-cell lineage. In this way, we first identified two MCL subgroups that respectively carry epigenetic imprints of pre- and post-germinal center B cells. Secondly, we observed that pure tumor-specific changes are rare, as most (89-99%) DNA methylation alterations in MCL are within or in close proximity of those regions showing dynamic methylation in normal B cells. Several thousand of these differentially methylated regions in MCL show concurrent changes in enhancer-associated histone modifications, including a region located 650 Kb away from the MCL oncogene SOX11. At the clinical level, epigenetic and genetic changes co-evolve during MCL progression and the magnitude of epigenetic changes is associated with overall survival of the patients.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00010001012 |
BLUEPRINT DNA Methylation 450K data of mantle cell lymphoma
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Illumina HumanMethylation 450K | 86 |
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