Study

BLUEPRINT DNA Methylation 450K data of mantle cell lymphoma

Study ID Alternative Stable ID Type
EGAS00001001637 Other

Study Description

We have applied an analytic strategy to decipher the DNA methylome of 86 mantle cell lymphomas (MCL) in light of the methylome of the entire B-cell lineage. In this way, we first identified two MCL subgroups that respectively carry epigenetic imprints of pre- and post-germinal center B cells. Secondly, we observed that pure tumor-specific changes are rare, as most (89-99%) DNA methylation alterations in MCL are within or in close proximity of those regions showing dynamic methylation in normal B cells. Several thousand of these differentially methylated regions in MCL show concurrent changes in enhancer-associated histone modifications, including a region located 650 Kb away from the MCL oncogene SOX11. At the clinical level, epigenetic and genetic changes co-evolve during MCL progression and the magnitude of epigenetic changes is associated with overall survival of the patients.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00010001012
BLUEPRINT DNA Methylation 450K data of mantle cell lymphoma
Illumina HumanMethylation 450K 86

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