Study
Comparing nodal versus bony metastatic spread using tumour phylogenies
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001001801 | Other |
Study Description
The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metastatic spread, suggesting the possibility of distinct aetiologies. To explore this, we traced patterns of cancer dissemination using tumour phylogenies inferred from genome-wide copy-number profiling of 48 samples across 3 patients with lymph node metastatic disease and 3 patients with osseous metastatic disease. Our results show that metastatic cells in regional lymph nodes originate from evolutionary advanced extra-prostatic tumour cells rather than less advanced central tumour cell populations. In contrast, osseous metastases do not exhibit such a constrained developmental lineage, arising from either intra or extra-prostatic tumour cell populations, at early and late stages in the evolution of the primary. Collectively, this comparison suggests that lymph node metastases may not be an intermediate developmental step for distant osseous metastases, but rather represent a ... (Show More)
Study Datasets 1 dataset.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00010001179 |
Tissue samples using Illumina HumanOmniExpress-FFPE-12 v1.0 BeadChip
|
Illumina HumanOmniExpress-FFPE-12 v1.0 BeadChip | 22 |
Who archives the data?

Publications
Citations
Retrieving...

Retrieving...
