Genetic subclone heterogeneity of tumor-initiating cells in human colorectal cancer

Study ID Alternative Stable ID Type
EGAS00001001857 Other

Study Description

A subset of tumor-initiating cells (TIC) drives colorectal cancer (CRC) progression in serial mouse xenografts. The TIC compartment itself is heterogeneous and comprises hierarchically organized long-term TIC, tumor transient amplifying cells, and delayed contributing TIC. To address the genomic heterogeneity of the CRC TIC compartment, genome-wide high-coverage whole genome sequencing was performed on patient tumors (n=3), corresponding serially passaged TIC-enriched spheres, and serial xenografts.HIPO P002

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
WGS from EGAS00001001857
Illumina HiSeq 2000 18
linking 3 samples out of EGAD00001002528 to EGAS0001004517
Illumina HiSeq 2000 3

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