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Genetic subclone heterogeneity of tumor-initiating cells in human colorectal cancer

A subset of tumor-initiating cells (TIC) drives colorectal cancer (CRC) progression in serial mouse xenografts. The TIC compartment itself is heterogeneous and comprises hierarchically organized long-term TIC, tumor transient amplifying cells, and delayed contributing TIC. To address the genomic heterogeneity of the CRC TIC compartment, genome-wide high-coverage whole genome sequencing was performed on patient tumors (n=3), corresponding serially passaged TIC-enriched spheres, and serial xenografts.HIPO P002

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002528 Illumina HiSeq 2000 18
EGAD00001006263 Illumina HiSeq 2000 3
Publications Citations
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer.
J Exp Med 214: 2017 2073-2088