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Whole transcriptome and exome sequencing of childhood ALL

Gene fusion is a major class of genomic abnormalities in childhood acute lymphoblastic leukemia (ALL) and sentinel chromosomal rearrangements involving EP300 and CREBBP may cause global epigenetic deregulation during leukemogenesis with potentials for therapeutic targeting. This dataset includes whole transcriptome sequencing of 231 children with acute lymphoblastic leukemia from a Singapore-Malaysia frontline clinical treatment protocol.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002151 Illumina HiSeq 2000 231
EGAD00001002152 Illumina HiSeq 2000 20
Publications Citations
Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.
Genome Res 27: 2017 185-195
Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.
Leukemia 32: 2018 2138-2151
Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias.
Haematologica 104: 2019 e200-e203
The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer.
High Throughput 8: 2018 E1
RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia.
Oncogene 40: 2021 746-762
Short H2A histone variants are expressed in cancer.
Nat Commun 12: 2021 490
Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia.
Blood Adv 5: 2021 5226-5238
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia.
Nat Commun 13: 2022 5401
USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
Blood Adv 7: 2023 3099-3112
TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data.
Blood Adv 7: 2023 7402-7406
DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers.
Elife 12: 2024 RP89017