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Periprostatic tissue obtained from patients with from high-risk prostate cancer has a distinct transcriptional profile

Purpose: Increasing evidence indicates that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of prostate cancer. As prostate tumours progress locally they frequently invade the periprostatic adipose compartment, gaining access to locally produced adipokines that have been associated with tumour cell growth, invasion and metastases. In this study we investigate the adipose transcriptional profiles of high-risk and low-risk disease to determine both prognostic potential and possible biological drivers of aggressive disease.Experimental Design: RNA was extracted from periprostatic and subcutaneous adipose tissue taken from patients categorised as having prostate cancer with either a high- or low-risk of progression by the D’Amico classification system and profiled by gene-expression microarray.Results: A clear separation was observed between the transcriptional profiles of high-risk and low-risk prostate cancer in periprostatic adipose tissue and a 10-gene signature consisting of CXORF39, PTGR1, CTNNA1, CDK8, TMEM64, LAMP3, LMO3, RGS16, SVEP1, and MEF2A, was able to separate high- and low-risk disease. Furthermore, similarities observed between periprostatic and subcutaneous adipose tissues may indicate a systemic contribution of adipose tissue to prostate cancer.Conclusions: Periprostatic adipose tissue is contributing to the tumour microenvironment of prostate cancer and affecting the progression of the disease.