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Spatiotemporal genomic architecture informs precision oncology in glioblsatoma

We characterized genomic and expression profiles across 127 multi-sector or longitudinal specimens from 52 glioma patients. We showed that, while samples from nearby geographical location shared similar genomic alterations (clonal or subclonal) and expression signatures, multifocal tumors were seeded from individual clones.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002248 Illumina HiSeq 2500 104
EGAD00001002249 Illumina HiSeq 2500 355
Publications Citations
Spatiotemporal genomic architecture informs precision oncology in glioblastoma.
Nat Genet 49: 2017 594-599
A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
Nat Cell Biol 20: 2018 1203-1214
Alternative polyadenylation of single cells delineates cell types and serves as a prognostic marker in early stage breast cancer.
PLoS One 14: 2019 e0217196
Glioma progression is shaped by genetic evolution and microenvironment interactions.
Cell 185: 2022 2184-2199.e16
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.
Genome Med 15: 2023 16