Study

Spatiotemporal genomic architecture informs precision oncology in glioblsatoma

Study ID Alternative Stable ID Type
EGAS00001001880 Other

Study Description

We characterized genomic and expression profiles across 127 multi-sector or longitudinal specimens from 52 glioma patients. We showed that, while samples from nearby geographical location shared similar genomic alterations (clonal or subclonal) and expression signatures, multifocal tumors were seeded from individual clones.

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
EGAD00001002248
Total of 49 tumor specimens from 20 patients were subjected for whole-exome and/or whole-transcriptome sequencing including matched normal/blood. Tumor samples are acquired based on 4 categories; 1) locally adjacent tumors, 2) multifocal/multicentric tumors, 3) 5-ALA (+/-) tumors and 4) Longitudinal tumors.
Illumina HiSeq 2500 104
EGAD00001002249
Single-Cell RNA Sequencing of 355 cells isolated from 7 tissue fragments of 3 patients corresponding to locally adjacent tumor, multifocal with recurrence and sections segregated by a marker of tumor cellularity (5-ALA).
Illumina HiSeq 2500 355

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