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Investigating genetic susceptibility to rheumatic heart disease in Oceania

This case-control study investigated susceptibility to rheumatic heart disease in over 3,000 individuals recruited across eight Oceanian countries. Cases were patients with rheumatic heart disease and controls were members of the general population. In addition to the Illumina HumanCore-24 BeadChip genotyping, a subset of 128 samples were analysed using the higher density Illumina HumanOmniExpressExome BeadChip of which 64 were also analysed using low coverage sequencing with the Illumina HiSeq 4000 platform.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002665 64
EGAD00010000953 HumanCore-24 BeadChip 937
EGAD00010000954 HumanCore-24 BeadChip 356
EGAD00010000955 HumanOmniExpressExome-8 BeadChip 32
EGAD00010000956 HumanOmniExpressExome-8 BeadChip 34
EGAD00010000957 HumanCore-24 BeadChip 465
EGAD00010000958 HumanOmniExpressExome-8 BeadChip 32
EGAD00010000959 HumanCore-24 BeadChip 854
EGAD00010000960 HumanCore-24 BeadChip 126
EGAD00010000961 HumanCore-24 BeadChip 535
EGAD00010000962 HumanOmniExpressExome-8 BeadChip 30
EGAD00010000963 HumanCore-24 BeadChip 24
Publications Citations
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
Nat Commun 8: 2017 14946
The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.
Sci Rep 10: 2020 9004