Investigating genetic susceptibility to rheumatic heart disease in Oceania

This case-control study investigated susceptibility to rheumatic heart disease in over 3,000 individuals recruited across eight Oceanian countries. Cases were patients with rheumatic heart disease and controls were members of the general population. In addition to the Illumina HumanCore-24 BeadChip genotyping, a subset of 128 samples were analysed using the higher density Illumina HumanOmniExpressExome BeadChip of which 64 were also analysed using low coverage sequencing with the Illumina HiSeq 4000 platform.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

12 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001002665	Mapped sequence reads in BAM format for 64 individuals reporting Kanak ancestry recruited in New Caledonia sequenced at four times target coverage using the Illumina HiSeq 4000 platform.		64
EGAD00010000953	Healthy adult volunteers and newborns recruited in various countries across Oceania.	HumanCore-24 BeadChip	937
EGAD00010000954	Healthy volunteers recruited in New Caledonia	HumanCore-24 BeadChip	356
EGAD00010000955	Rheumatic heart disease cases recruited in Fiji with higher density genotyping	HumanOmniExpressExome-8 BeadChip	32
EGAD00010000956	Rheumatic heart disease cases recruited in New Caledonia with higher density genotyping	HumanOmniExpressExome-8 BeadChip	34
EGAD00010000957	Rheumatic heart disease cases recruited in New Caledonia	HumanCore-24 BeadChip	465
EGAD00010000958	Healthy volunteers recruited in Fiji with higher density genotyping	HumanOmniExpressExome-8 BeadChip	32
EGAD00010000959	Healthy volunteers recruited in Fiji	HumanCore-24 BeadChip	854
EGAD00010000960	Definite and borderline rheumatic heart disease cases and patients with mild non-diagnostic valvulopathy recruited in Samoa	HumanCore-24 BeadChip	126
EGAD00010000961	Rheumatic heart disease cases recruited in Fiji	HumanCore-24 BeadChip	535
EGAD00010000962	Healthy volunteers and missing phenotype individuals recruited in New Caledonia with higher density genotyping	HumanOmniExpressExome-8 BeadChip	30
EGAD00010000963	Healthy volunteers recruited in Samoa	HumanCore-24 BeadChip	24

Publications	Citations
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania. Parks T, Mirabel MM, Kado J, Auckland K, Nowak J, Rautanen A, Mentzer AJ, Marijon E, Jouven X, Perman ML, Cua T, Kauwe JK, Allen JB, Taylor H, Robson KJ, Deane CM, Steer AC, Hill AVS, Pacific Islands Rheumatic Heart Disease Genetics Network. Nat Commun 8: 2017 14946	53
The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans. Auckland K, Mittal B, Cairns BJ, Garg N, Kumar S, Mentzer AJ, Kado J, Perman ML, Steer AC, Hill AVS, Parks T. Sci Rep 10: 2020 9004	6