Study

Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies

Study ID Alternative Stable ID Type
EGAS00001001909 Other

Study Description

To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). Laser capture microdissection of tumour islets was performed on samples prior to chemotherapy, after three cycles of chemotherapy and at recurrence. Long frament read whole genome sequencing was performed and mutations were identified. To our knowledge, this is the first longitudinal study that attempts to investigate spatial and temporal micro-heterogeneity in cancer.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001002734
Whole Genome Sequencing data set for the study "Premalignant SOX2 in ovarian cancer patients"
Complete Genomics 39

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