Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Presurgical studies allow study of the relationship between mutations and response of estrogen receptor positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in Phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 Controls). In poor responders (based on Ki67 change) we find significantly more somatic mutations than good responders. Subclones exclusive to baseline or ... (Show More)
|Illumina HiSeq 2000||443|