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CRC Promoter capture Hi-C

Genome organisation determines chromosome interactions between regulatory elements, such as promoters and enhancers, influencing gene expression. Despite the fact that it is possible to assess whether a gene is actively transcribed, it has been challenging to point out the genomic regions that are involved in the regulation of a particular gene. We are interested in better understanding the interactions between promoters and their regulatory elements in colorectal cancer in order to unveil novel non-coding regions which might have a role in tumour development. To do so, we utilise the HiC method complemented with promoter capture in combination with NGS to map promoter interactions in two CRC cell lines, representing two distinct CRC subtypes.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003257 Illumina HiSeq 2000 2
EGAD00001003258 Illumina HiSeq 2000 2
Publications Citations
Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer.
Nat Genet 50: 2018 1375-1380
The Identification and Interpretation of cis-Regulatory Noncoding Mutations in Cancer.
High Throughput 8: 2018 E1
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Nat Commun 10: 2019 2154
Algorithmic considerations when analysing capture Hi-C data.
Wellcome Open Res 5: 2020 289