Need Help?

Chromosome contacts in activated T cells identify autoimmune disease-candidate genes

Autoimmune disease-associated DNA variants are preferentially found in regions with putative regulatory function in immune cells, particularly CD4+ T cells. Linking such regulatory elements to gene promoters in disease-relevant cells and contexts is essential to identify disease candidate genes. Here we show that the activation of CD4+ T cells invokes changes in the activity of regulatory elements and transcription of RNAs that correspond to changes in the expression of their interacting genes identified by promoter capture Hi-C (PCHi-C).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002686 Illumina HiSeq 2000 42
EGAD00001002687 Illumina HiSeq 2000 4
Publications Citations
Chromosome contacts in activated T cells identify autoimmune disease candidate genes.
Genome Biol 18: 2017 165
43