Chromosome contacts in activated T cells identify autoimmune disease-candidate genes
|Study ID||Alternative Stable ID||Type|
Autoimmune disease-associated DNA variants are preferentially found in regions with putative regulatory function in immune cells, particularly CD4+ T cells. Linking such regulatory elements to gene promoters in disease-relevant cells and contexts is essential to identify disease candidate genes. Here we show that the activation of CD4+ T cells invokes changes in the activity of regulatory elements and transcription of RNAs that correspond to changes in the expression of their interacting genes identified by promoter capture Hi-C (PCHi-C).
Study Datasets 2 datasets.
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CD4 T-Cell ChIP-Seq
|Illumina HiSeq 2000||42|
CD4 T-Cell RNA-Seq
|Illumina HiSeq 2000||4|
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