Study
Chromosome contacts in activated T cells identify autoimmune disease-candidate genes
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001001961 | Other |
Study Description
Autoimmune disease-associated DNA variants are preferentially found in regions with putative regulatory function in immune cells, particularly CD4+ T cells. Linking such regulatory elements to gene promoters in disease-relevant cells and contexts is essential to identify disease candidate genes. Here we show that the activation of CD4+ T cells invokes changes in the activity of regulatory elements and transcription of RNAs that correspond to changes in the expression of their interacting genes identified by promoter capture Hi-C (PCHi-C).
Study Datasets 2 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001002686 |
CD4 T-Cell ChIP-Seq
|
Illumina HiSeq 2000 | 42 |
| EGAD00001002687 |
CD4 T-Cell RNA-Seq
|
Illumina HiSeq 2000 | 4 |
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