Chromosome contacts in activated T cells identify autoimmune disease-candidate genes

Study ID Alternative Stable ID Type
EGAS00001001961 Other

Study Description

Autoimmune disease-associated DNA variants are preferentially found in regions with putative regulatory function in immune cells, particularly CD4+ T cells. Linking such regulatory elements to gene promoters in disease-relevant cells and contexts is essential to identify disease candidate genes. Here we show that the activation of CD4+ T cells invokes changes in the activity of regulatory elements and transcription of RNAs that correspond to changes in the expression of their interacting genes identified by promoter capture Hi-C (PCHi-C).

Study Datasets 2 datasets.

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Dataset ID Description Technology Samples
CD4 T-Cell ChIP-Seq
Illumina HiSeq 2000 42
CD4 T-Cell RNA-Seq
Illumina HiSeq 2000 4

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